イケダ　ハルカ   Haruka Ikeda   池田　東香    所属   追手門学院大学  心理学部 心理学科    追手門学院大学  大学院　心理学研究科    職種   特任助教
言語種別	英語
発行・発表の年月	2013/12/30
形態種別	論文
査読	査読あり
標題	Prefrontal dysfunction in remitted depression at work reinstatement using near-infrared spectroscopy.
執筆形態	共著・編著（代表編著を除く）
掲載誌名	Psychiatry research
掲載区分	国外
巻・号・頁	214(3),pp.254-9
著者・共著者	Eiji Ikeda,Kazumasa Shiozaki,Haruka Ikeda,Michio Suzuki,Yoshio Hirayasu
概要	A long-term and/or recurrent sickness absence from work due to depression has been an important health problem in industrial countries. In addition, previous sick leave is a risk factor of recurrence. However, many characteristics, especially biological aspects, have not been investigated in remitted depressive patients who were ready to return to work from sickness absence. Therefore, the purpose of this study is to clarify the pathophysiological characteristics of patients who were at risk for recurrence of sickness absence. We recruited 21 patients and 16 healthy control subjects. All patients were ready to return to work within one month from long-term sickness absence. All subjects were examined for prefrontal function represented by oxyHb changes during the verbal fluency task (VFT) and the Stroop task using near-infrared spectroscopy. Suppressed prefrontal reaction during the VFT and increased prefrontal reaction during the Stroop task were observed in the patient group compared with the control group. Significantly lengthened reaction time was observed in the incongruent condition in the patient group during the Stroop task. Depressive patients showed impaired executive function measured by the Stroop task and had prefrontal dysfunction despite clinical remission. Residual prefrontal dysfunction may be one biological reason for repetitive sickness absence.
DOI	10.1016/j.pscychresns.2013.07.009
PMID	24139959